Best Water Soluble CBD Oil Products Reviewed for 2025
Soubhik ChakrabartiFollow us on 
Though very similar in their overall chemical constitution, water-soluble and fat-soluble CBD products differ in their range of bioavailability. In contrast to oil-based products, water-soluble CBD oils allow more CBD to be absorbed into the system leading to increased effectiveness. So if you are looking for a product that works faster and better than traditional CBD oil, this is your oil.
Discover The Best Water Soluble CBD Oil Brand in 2025
Water soluble CBD oils are in high demand owing to their significantly higher bioavailability. But to get the intended benefits, finding a trustworthy brand using high-grade ingredients is crucial. For this reason, we've selected the following products to help you get an improved CBD experience.
American Shaman: Water Soluble CBD Hemp Oil
American Shaman's Water Soluble CBD Oil is an American-made product that promises up to 10 times more bioavailability than conventional oils. The brand also offers five different flavours like pina colada and limeade, so finding a taste that works for you won't be difficult.
Recommended Dosage: 20 mg CBD daily twice a day. The maximum daily intake should not be more than 60 mg.
Pros:
- This product offers 10X the bioavailability of traditional CBD oil.
- High CBD concentration of 10 mg per every 1 ml dropper.
- The oil is available in flavours like cherry limeade, pina colada, hemp, grape, and lemon.
- This oil is made using proprietary nanotechnology to break down the particles.
Cons:
- The product may require higher amounts to produce the intended effect.
How Did We Pick These Water Soluble CBD Brands?
Several factors are crucial when choosing the best water-soluble brands/products. Brand reputation is always essential when picking these oils. Good reactions to past projects, especially regarding product quality, help build up the image of these companies. You will find products made using the best quality hemp and the most precise extraction methods when you buy from these brands.
Aside from this appeal, we also look closely at real-life applications of these oils to see how they function in real-world applications. The reviews verified users offer on the brands' websites help us get a more informed opinion of these products. Lastly, since the CBD market is still largely unregulated, we believe it is our responsibility to find products for you that are safe and legal to use.
All the water-soluble CBD oils on this list pass the legal requirements on their THC content, so you can enjoy them without worrying about getting into legal trouble.
How to Choose the Best Water Soluble CBD Oil?
Referring to the product labels is a great way to ensure quality purchase when looking for water soluble CBD oil. Oils come in different variants, like full spectrum, broad spectrum, and CBD Isolate, each with specific uses. For example, since it contains all the necessary cannabis extracts, full spectrum CBD is used to treat more acute symptoms in patients.
When you read the product labels carefully, you can find an oil that suits your condition best. Additionally, other than Epidiolex, a CBD-based drug used to treat two specific forms of epilepsy, no CBD product has been cleared for medical use. Using this information, you can weed out those oils that make medical claims.
For water soluble CBD oils, the production technology is more crucial than regular CBD oils. The bioavailability of the product depends on this process. For this reason, you ought to insist on the details of the chemical composition of the oil during purchase. You can also ask the brand to provide manufacturing details, if possible, to check whether the water-soluble CBD oil is as effective as the claims.
Water Soluble CBD Products Can Provide Best Absorption Regarding a New Study
In a recent article, Forbes reported on a study conducted by the Colorado State University on the best absorption techniques/capabilities among CBD products. All four male participants were given doses of various CBD oils, including CBD ISolate, oil-soluble, and water-soluble CBD oil.
This test revealed that water soluble CBD oil had 500% more maximum blood concentration variation than oil-based CBD. This study showed that this form of CBD provided the best absorption rate, especially when taken alongside food. Typically, CBD oil lasts in the body for about three hours, even lesser when consumed alongside food or drink.
The researchers at Colorado State found that water-soluble CBD was present in the blood in a significant percentage up to 6 hours after initial dosing. Additionally, the substance seemed to have interacted extremely with the food, positively affecting fat and sugar metabolization.
Potential Benefits of Using Water Soluble CBD
Based on studies like the ones mentioned above, the chief potential benefits of water soluble CBD can get segregated into the following categories:
Faster Effect Time
Typically, with orally administered CBD, it takes anywhere between 10 to 30 minutes for the effects of CBD to kick in. Since the cannabidiol in these products comes infused in oils like MCT or hemp seed, they must get broken down first before the body can take in the CBD.
With water soluble CBD, there is no waiting time, as the solution gets absorbed by the body as soon as it enters the system. Unlike traditional CBD oils, you do not have to wait till the digestive system breaks down the product. Due to their high solubility, they enter the bloodstream as soon as you ingest the water soluble CBD.
Best Product to Use with Food and Drink
Even though most CBD products can be used with food, water soluble CBD is the best product to pair your morning coffee or evening salad with. Studies show that this solution lasts twice as long in the system when consumed with food compared to conventional CBD oils. Water soluble CBD also enhances the metabolization of sugars and glucose in the food as it can dissolve more easily in your drink or meal.
Less loss of CBD
The absorption is almost immediate when you use water soluble CBD. Studies show that, in oral methods, as many as 96% of the CBD goes to waste as it passes through multiple processes to enter the bloodstream. With water-soluble products, the CBD is broken down into nanoparticles to optimize direct, through-the-cell-absorption, meaning there is minimal loss of CBD.
Water Soluble CBD Oil: Why Bioavailability Matters
Bioavailability refers to the rate at which a substance is available for absorption into a living system. So, in CBD, it means the amount of cannabidiol accessible to the body. In conventional CBD oils, especially those taken orally, this can be as low as 4%.
This is because these substances are fat-soluble, meaning that during absorption, only a partial amount of the CBD gets absorbed through the cells' lipid bilayer, as oil-based products are more difficult to absorb.
With water soluble CBD, this is not the case because the CBD in these products is broken down into minute nanoparticles to ensure optimum absorption. CBD molecules are exposed to sound waves that break them down to one billionth of a meter.
The size of the particles ensures that the water-soluble CBD molecules get absorbed easily by the cell walls. This way, more CBD enters the bloodstream and the cells, producing the intended benefits.
Is it Legal to Buy Water Soluble CBD Oil?
As a product made using cannabis extract, water soluble CBD falls under the same legal restrictions as other best CBD oils. By extension of the 2018 Farm Bill, the FDA allows the federal use of hemp-based products that contain 0.3% THC or less. Any water soluble CBD which exceeds this THC content is considered illegal federally.
However, cannabis use is legal in 19 US states, including Colorado, Oregon, and California. Therefore to ensure there are no issues with legality, you should check up on your local laws before purchasing water soluble CBD oils.
Final Thoughts: Is It Worth Using Water Soluble CBD Oil?
A water-soluble CBD oil is a no-brainer if you enjoy your CBD best with your morning coffee or juice. Not only does it work better with food items, but it also lasts longer while providing prolonged benefits. The higher bioavailability of this product ensures that more CBD per drop enters your bloodstream, leading to an enhanced CBD experience.
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